Urinary Tract Infections
Trimethoprim alone has been shown to be effective against common strains of urinary tract pathogens including1:
- Escherichia coli
- Enterobacter species
- Klebsiella pneumoniae
- Proteus mirabilis
- Staphylococcus saprophyticus
PRIMSOL Solution is The Only Oral Solution Trimethoprim Available4.
- Some patients may require or benefit from a liquid UTI treatment
- Dysphagia affects a significant number of elderly patients
- Up to 68% of elderly nursing home residents5
- Up to 30% of elderly admitted to the hospital6
- Up to 64% of patients after stroke7,8
- 13%–38% of elderly who live independently9,10,11
Trimethoprim Antibacterial Activity is Not Increased by Adding Sulfamethoxazole for Escherichia coli Urinary Tract Infection2
Allergic reactions to sulfa antimicrobials including urticaria, erythroderma and macular exanthema may develop in some patients.2,3
The usual oral adult dosage for Uncomplicated Urinary Tract Infections is:
- 100 mg (10 mL) every 12 hours for 10 days, or
- 200 mg (20 mL) every 24 hours for 10 days
- Primsol® Package Insert. Aytu Pharmaceuticals, Inc. Englewood, CO; 2015.
- Nguyen HT et al. Trimethoprim In Vitro Antibacterial Activity is Not Increased by Adding Sulfamethoxazole for Pediatric Escherichia coli Urinary Tract Infection. Urology. 2010; 184, 305-310.
- Brackett CC: Sulfonamide allergy and cross-reactivity. Curr Allergy Asthma Rep 2007; 7: 41.
- Electronic Orange Book. Food and Drug Administration website. http://www.fda.gov/cder/ob/default.htm/. October 2015. Accessed October 1, 2015.
- Steele CM, Greenwood C, Ens I, Robertson C, Seidman-Carlson R. Mealtime difficulties in a home for the aged: not just dysphagia. Dysphagia. 1997;12:43–50, discussion 51.
- Lee A, Sitoh YY, Lieu PK, Phua SY, Chin JJ. Swallowing impairment and feeding dependency in the hospitalised elderly. Ann Acad Med Singapore. 1999;28:371–376.
- Mann G, Hankey GJ, Cameron D. Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke. 1999;30:744–748.
- Smithard DG, O’Neill PA, Parks C, Morris J. Complications and outcome after acute stroke. Does dysphagia matter? Stroke. 1996;27:1200–1204.
- Kawashima K, Motohashi Y, Fujishima I. Prevalence of dysphagia among community-dwelling elderly individuals as estimated using a questionnaire for dysphagia screening. Dysphagia. 2004;19:266–271.
- Serra-Prat M, Hinojosa G, López D, et al. Prevalence of oropharyngeal dysphagia and impaired safety and efficacy of swallow in independently living older persons. J Am Geriatr Soc. 2011;59:186–187.
- Roy N, Stemple J, Merrill RM, Thomas L. Dysphagia in the elderly: preliminary evidence of prevalence, risk factors, and socioemotional effects. Ann Otol Rhinol Laryngol. 2007;116:858–865.